Endocrine Abstracts

The work was initiated to assess and monitoring of basic epidemiological parameters of type 1 DM among children in the course of the 2000–2007 National Register. Epidemiological data was studied on the basis of annual reports from 13 regional endocrinological dispensaries and Tashkent endocrinological dispensary as well as on the basis of register cards filled up by local endocrinologists–pediatricians. In Uzbekistan within the period from 2000 to 2007 type 1 DM prev...

The work was initiated to assess clinical-diagnostic value of urinary α-glucosidase activity in predicting chronic renal insufficiency in type 1 diabetes mellitus in Uzbek children and adolescents. We examined 152 children and adolescents of the Uzbek population, 122 children and adolescents with type 1 diabetes mellitus (51 male and 71 female). By proteinuria the patients were divided into three groups: with normoalbuminuria (NAU) (n=52), with microalbuminuria (...

Background: Insulin pumps, devices for continuous subcutaneous insulin infusion have become fundamentally new and progressive step in the treatment of diabetes. To date, there has been no experience with the use of insulin pumps in UzbekistanAims and objectives: To evaluate the effectiveness of insulin pump therapy in comparison with the regime of multiple daily injections (MDI) of insulin.Materials and methods: Forty children and ...

Background: The COVID-19 pandemic has caused enormous damage to all countries of the world. Patients with diabetes mellitus are a separate risk group for the consequences of COVID-19, both in the acute and in the long-term period.Aim: To study change in the structure of mortality among patients with diabetes in the Republic of Uzbekistan during the COVID-19 pandemic.Materials and Methods: We analyzed the data of the report forms of...

Background: Since the very first outbreak, scientists have been trying to determine the most critical pathogenetic mechanisms for the development of COVID-19 and related complications, analyze individual subpopulations of patients with chronic diseases and develop optimal tactics to combat not only the infection itself but also its acute and chronic complications.Aim: to identify and analyze factors influencing the severity of the COVID-19 course among p...

Prevention of familial diabetes mellitus is a most urgent problem in diabetology. Genetic susceptibility is a leading factor in diabetes mellitus onset.Aim: The work was initiated to assess potentiality of diabetes mellitus risk prediction based on genealogical analysis.Materials and methods: For the purpose of the study, 53 patients with diabetes mellitus were examined. The probands’ mean age was 14.4 years. Genealogical medi...

The fat tissue inflammation and insulin resistance formation are common in obesity and type 2 diabetes mellitus. The tumor necrosis factor–α (TNF-α), a pro-inflammatory cytokine, was found to be a key one in onset and progression of insulin resistance, blocking the insulin signaling pathway and hampering the gene expression of GLUT4, the intracellular insulin-regulated glucose transporter in body tissues. Rise in the TNF-α concentration in blood serum is b...

Testing for genetic markers is a promising approach in early diagnosis of type 1 diabetes mellitus (DM1). Of all DM1-associated genes and genetic loci, after HLA class II, insulin promoter gene confers the highest risk for the onset of disease with the burdened familial history for diabetes mellitus.Materials and methodsGenealogical analysis was used to identify the hereditary nature of the disease. DNA samples from 94 Uzbek patien...

Diabetes mellitus (DM) is a most significant medical-social worldwide problem. Absence of reliable screening program for identification of persons with the higher risk of DM dictates a necessity of sensitive tests of early DM diagnosis. Following genealogical analysis, two experimental groups were formed; patients with type 1 DM with the familial burden (probands) and those at risk (siblings) were included into the 1st and 2nd groups, respectively. Apparently healthy subjects ...